Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis
نویسنده
چکیده
Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum's trypanolytic action.
منابع مشابه
Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause sleeping sickness in humans. T. b. brucei fails to infect humans because it is sensitive to innate immune complexes found in normal h...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014